Quick answers
Who counters Senna in Wild Rift?
In the matchup data documented in Rift Lab, these are the harder matchups for Senna: Blitzcrank (Support), Pyke (Support), Nautilus (Support), Leona (Support), Thresh (Support). This is a documented matchup list, not a win rate: TheNexus does not publish win-rate or pick-rate figures it cannot source.
How do you play against Senna in Wild Rift?
Riot's ability text for Senna describes a shield in DAWNING SHADOW (ultimate). Plan around those abilities before a trade or a fight. These notes are keyword matches over the ability text only, not a rating of how strong Senna is, so read the full descriptions on this page.
What is the best build for Senna in Wild Rift?
The Nexus-reviewed core build for Senna, in purchase order: Magnetic Blaster then Serpent's Fang then Mortal Reminder then Boots of Dynamism then Galeforce. Runes: Fleet Footwork, Empowered Attack, Chain Assault, Zombie Ward, Bone Plating. This is a reviewed snapshot (patch 7.2b), not a build ranked by win rate.
Which lane and role does Senna play in Wild Rift?
Senna is a Marksman and Support by Riot's classification and is played in Support. Riot rates the difficulty High. On our tier-list snapshot (patch 7.2b) it shows S tier from its external source, which is a snapshot letter and not a TheNexus win rate.
Every answer here is built from Rift Lab data and Riot's own ability text. Where the data is missing we say so instead of guessing.